Protein Details: Gap junction beta-2 protein

Protein ID

ICDB_Pro_0403

Protein Name

Gap junction beta-2 protein

Gene Name

Gjb2; Cxn-26

Organism

Rattus norvegicus (Rat)

Length

226 amino acids

AlphaFoldDB

AF-P21994-F1-model_v4.pdb

Function

Sequence

MDWGTLQSILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIMVSTPALLVAMHVAYRRHEKKRKFMKGEIKNEFKDIEEIKTQKVRIEGSLWWTYTTSIFFRVIFEAVFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDCFISRPTEKTVFTVFMISVSGICILLNITELCYLFIRYCSGKSKRPV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Liver; kidney; intestine; lung; spleen; stomach; testis and brain; but not heart and adult skeletal muscle

DOI ID

10.1083/jcb.109.6.3391; 10.1101/gr.2596504; 10.1038/329732a0; 10.1093/hmg/ddp490

RefSeq

NP_001004099.1; XP_017455254.1